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KMID : 0364219900330040454
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Korean Journal of Zoology
1990 Volume.33 No. 4 p.454 ~ p.460
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The Effect of Acrylamide on the Ultrastructures of Nervous System of the Mouse
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Kim Dong-Soo
Hah Jae-Chung
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Abstract
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The effed of acrylamide on the nervous system has heen morphologically studied using light and electron microscopes. The light micrographs on central and pedpheral nervous tissues of mouse treated with acrylamide monomer showed total vacuolation of spinal cord, cell degradation containing neuron and neuroglia, and distal nerve fiber degeneration. The electron micrographs showed ultrastrudural changes. Abnormal mitochondria in neuron, splitting of myelin sheath in lumbar ventral root nerve, partial disintergration of myelin sheath and axoplasmic degeneration in sciatic nerve, and overafl polyneuropathies in nervous system were observed. These results suggest that acrylarnide intoxicated mouse shows distal behavioral neuropathy as an earlist clinical sign, but the initial effect of acrylamide on the nervous system seems to appear at nearly the same time in both central and peripheral nervous systems.
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KEYWORD
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Acrylamide, Neuropathy, Ultrastructure, Nervous system
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